Original Publication Date: >1 May, 2015
Publication / Source: Epigenomics
Authors: Hamid Mostafavi Abdolmaleky, Jin-Rong Zhou & Sam Thiagalingam
The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide studies of postmortem brain and blood cells indicating that aberrant DNA methylation, histone modifications and dysregulation of micro-RNAs are linked to the pathogenesis of mental diseases.