Original Publication Date: >5 June, 2015
Publication / Source: Personalized Medicine
Authors: Katalin Tóth, Tamás Bűdi & Ádám Kiss et al.
Aim: Since prominent role in valproate metabolism is assigned to CYP2C9 in pediatric patients, the association between children’s CYP2C9-status and serum valproate concentrations or dose-requirements was evaluated. Materials & Methods: The contribution of CYP2C9 genotype and CYP2C9 expression in children (n = 50, Caucasian) with epilepsy to valproate pharmacokinetics was analyzed.