Toward nonsystemic delivery of therapeutics across the blood–brain barrier

The blood–brain barrier (BBB) prevents the entry of 98% of drugs to the CNS, which poses an enormous challenge for cerebral disease treatment. A study now demonstrates a new safe technique to temporally open the BBB and deliver drugs into the CNS. The demanding function of the neural tissue in the brain requires an extremely stable environment. In fact, any small change in the composition of the interstitial fluid in the CNS plays a predominant role in regulating the brain microenvironment and neuronal activity. Therefore, the brain is conceived to protect itself from frequent fluctuations of extracellular concentration of hormones,...