Newly identified haplotype could aid in delaying the onset of Alzheimer’s disease

Genome-wide association testing, carried out by researchers at the University of California Santa Barbara (CA, USA), has identified a novel haplotype of single-nucleotide polymorphisms (SNPs) in a gene cluster believed to be linked to neuroinflammation. In individuals with early-onset Alzheimer’s, the haplotype was associated with a relatively delayed onset of Alzheimer's disease (AD), retarding the age of onset (AOO) by up to 10 years. The findings were published recently in Molecular Psychiatry. AD is currently ranked among the top ten causes of death in the world with the risk of disease development being amplified exponentially with age after 65. The...