Neurology Central

Latest research into the effects of traumatic brain injury

New research presented at Society for Neuroscience’s annual meeting, Neuroscience 2015 (17—21 October 2015), in Chicago (IL, USA) has revealed new discoveries regarding symptoms, physiology and treatment options for traumatic brain injury (TBI).

In particular, four highlighted animal studies have demonstrated evidence of differences in TBI manifestation in males versus females and adults versus children. Among work presented at the conference, the following studies were highlighted:

– Considering gender differences in long-term consequences of mild TBI (mTBI), Ramesh Raghupathi (Drexel University, PA, USA) has demonstrated that female mice have increased sensitivity to touch up to 8 weeks post mild TBI. In contrast, male mice at the same time point display more depressive behaviours on a forced swim test. These data also raise question as to the duration of such symptoms, with the groups’ previous reports having suggested such deficits resolve within a week.

– Presenting on fear behaviours in mice following mTBI from a blast, Carmen Lin from Northwestern University (IL, USA) demonstrated that exposed fear conditioned mice with TBI exhibited increased freezing when replaced in the fear-associated environment compared with conditioned non-injured controls. These novel findings suggest an element of emotional disturbance in fear learning in injured animals, which may be linked to post-traumatic stress disorder.

– Michael Ayo Sangobowale (SUNY, NY, USA) presented promising work at the conference demonstrating potential for the use of minocycline and N-acetylcysteine up to 6- and 12-hours post-injury, with treated mice outperforming placebo treated controls on Barnes maze testing.

– New data presented by Trent Anderson from University of Arizona (AZ, USA) has compared the effects of TBI in juvenile and adult mice. The study observes a difference in TBI response between the two groups, with pediatric brains showing a reduction in brain inhibition.

It is hoped that these studies will serve to further our understanding of TBI, in addition to allowing us to better develop treatments. These hopes were summarized by brain injury expert Akiva Cohen (University of Pennsylvania, PA, USA), who stated: “Today’s findings show the progress we’ve made in understanding TBI. By better understanding aspects of TBI — like gender and age differences — we can create treatments that are better targeted to the distinct problems in different populations of people.”

All abstracts from Neuroscience 2015 are available at
Source: Society for Neuroscience, Neuroscience 2015 Press Release.