Prognostic significance of BRCA1 expression defined in glioblastoma multiforme

The prognostic significance of BRCA1 protein expression in glioblastoma multiforme (GBM) tumors has been determined for the first time. An investigation carried out by the Radiation Therapy Oncology Group assessed four distinct molecular biomarkers in GBM, the results of which suggested that BRCA1 was the sole marker to correlate with overall survival. The findings were reported at the recent Annual Meeting of the American Society for Radiation Oncology (18–21 October 2015, TX, USA). Patients with GBM tumors expressing low levels of BRCA1 were demonstrated to be associated with prolonged survival when compared with GBM patients with tumors expressing higher levels...