Neurology Central

Mild cognitive impairment: an update in Parkinson’s disease and lessons learned from Alzheimer’s disease


Cognitive dysfunction is an important focus of research in Parkinson’s disease (PD) and Alzheimer’s disease (AD). While the concept of amnestic mild cognitive impairment (MCI) as a prodrome to AD has been recognized for many years, the construct of MCI in PD is a relative newcomer with recent development of diagnostic criteria, biomarker research programs and treatment trials. Controversies and challenges, however, regarding PD-MCI’s definition, application, heterogeneity and different trajectories have arisen.

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