Original Publication Date: >20 October, 2015
Publication / Source: Biomarkers in Medicine
Authors: Michael J Goldenthal, Shirish Damle & Sudip Sheth et al.
Aim: Mitochondrial function studies in autism spectrum disorders (ASD) have detected skeletal muscle mitochondrial enzyme deficiencies in respiratory complex (RC) activities. As a muscle biopsy is expensive and invasive, we assessed RC-I and RC-IV activities in buccal swabs. Methods: 92 children with ASD and 68 controls were studied with immunocapture for RC-I and microspectrophotometry for RC-IV.