Authors: Alice Weatherston
New research led by biomedical engineer Lingyan Shi from The City College of New York (NY, USA) has highlighted a novel opportunity for high quality deep brain imaging. The newly developed technique holds promise for the noninvasive evaluation of the brain, as well as other hard-to-image tissues, in greater detail than previously achievable. The study was published recently in the Journal of Biophotonics.
Shi’s team utilized light at 1600–1880nm and were able to prove both theoretically and experimentally that the wavelength was capable of high-resolution deep brain imaging.
Previously, near-infrared radiation using one and two-photon fluorescence imaging at wavelengths 650–950 nm has been the chosen method for deep brain imaging, a technique known as optical window 1.
The new research incorporates three new optical windows in the near-infrared radiation region and is capable of imaging deeper brain tissues due to a reduction in the scattering of light usually responsible for blurring within images.
The next step for the team in the development of this next generation microscopy technique is to test the wavelengths capacity for in vivo imaging in mice.
Source: The City College of New York press release: https://www.ccny.cuny.edu/news/ccny-researchers-open-%E2%80%9Cgolden-window%E2%80%9D-deep-brain-imaging