Novel proteins linked to Huntington’s Disease

The genetic mutation in the Huntingtin gene present in Huntington’s disease patients may result in a ‘cocktail’ of mutant proteins capable of accumulating in the brain, a new University of Florida Health (FL, USA) study has suggested. The findings were presented recently in Neuron. The team of researchers closely analyzed post-mortem brains of 12 individuals with Huntington’s Disease and identified five proteins in abundance in areas of the brain exhibiting neuronal loss, cell death and other key disease signatures such as neuroinflammation. While one of the proteins contributing to the disease pathology had previously been associated with Huntington’s Disease, the...