Original Publication Date: >2 November, 2015
Publication / Source: Future Neurology
Authors: Kamal KE Gadalla, Paul D Ross, Ralph D Hector et al.
Rett syndrome (RTT) is a neurological disorder that affects females and is caused by loss-of-function mutations in the X-linked gene MECP2. Deletion of Mecp2 in mice results in a constellation of neurological features that resemble those seen in RTT patients. Experiments in mice have demonstrated that restoration of MeCP2, even at adult stages, reverses several aspects of the RTT-like pathology suggesting that the disorder may be inherently treatable.