Abnormal axonal growth in CFEOM3 could be prevented through introduction of mutation in kinesin protein

Written by Courtney Johnson

In a study carried out at the RIKEN Brain Science Institute (Wako City, Saitama, Japan), researchers have utilized both transfected cell-expression systems and in vivo mouse models to investigate the effect of a novel mutation on the abnormal axonal growth of neurons characteristic of congenital fibrosis of the extraocular muscles type 3 (CFEOM3). The findings were published recently in Nature Communications. The research team introduced a new mutation into specific kinesin proteins in order to examine its impact on the kinesin interaction with β3-tubulin – the protein containing the disease-causing mutation in CFEOM3. The abnormal axonal growth observed in CFEOM3...

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