Original Publication Date: >14 March, 2016
Publication / Source: Pain Management
Authors: Shafaq Sikandar, Eske Kvanner Aasvang & Anthony H Dickenson
Although most pain research focuses on skin, muscles, joints and viscerae are major sources of pain. We discuss the mechanisms of deep pains arising from somatic and visceral structures and how this can lead to widespread manifestations and chronification. We include how both altered peripheral and central sensory neurotransmission lead to deep pain states and comment on key areas such as top–down modulation where little is known.