Neurology Central

Is there a link between higher levels of NMNAT2 and better cognitive function?

Hui-Chen Lu, a Gill Professor at the IU Bloomington College of Arts and Sciences (IN, USA), and her team have recently completed a study involving the examination of nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) levels in postmortem brain tissue of more than 500 elderly patients; hinting to the potential of NMNAT2 as a neuroprotective agent against degeneration.

The study, which was also carried out in collaboration with researchers from the Baylor College of Medicine (TX, USA), Massachusetts Institute of Technology, Rush University (IL, USA), University of Texas and Harvard University (MA, USA), indicated that NMNAT2 is ”a key neuronal maintenance factor” due to its exertion of both enzyme and chaperone functions.

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