Alzheimer’s-associated memory loss in mice prevented with targeted protein removal

Recent findings published in the Journal of Clinical Investigation have identified a protein, Ephexin5, that could be targeted to prevent and treat the systems of Alzheimer’s disease (AD). Studies in mice demonstrated that blocking the protein’s expression led to a reduction in cognitive impairment in mouse AD models, therefore making it a promising therapeutic target for the treatment of AD. In this study, researchers at the Johns Hopkins University School of Medicine (MA, USA) focused their research on Ephexin5, which previous research has shown to be required for the development of dendritic spines. Graduate student at John Hopkins University, Gabrielle...