Neurology Central

NF-ƙB-TNFα signaling implicated in frontotemporal dementia

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Researchers from the Gladstone Institute of Neurological Disease (University of California; CA, USA) have identified the neurological impact of a mutation in the progranulin gene associated with frontotemporal dementia (FTD). In this latest study, genetic manipulation to delete the progranulin protein from microglia resulted in obsessive like behaviors and social withdrawal in murine models.
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