Multiple concussive injuries could be associated with altered synaptic connections in the brain

A new study, published online in Neurology, suggested for the first time that the long-term complications caused by suffering multiple concussions could be associated with alterations to the metabolism and processing of amyloid precursor protein (APP) in the brain. These findings could lead to the development of novel therapeutics that target and treat these long-term complaints. In this study, researchers at the University of Gothenburg (Gothenburg, Sweden) investigated the link between post-concussion syndrome (PCS) and repetitive concussive traumatic brain injury. In total, 28 professional athletes were assessed with lumbar puncture, MRI of the brain, and the Rivermead Post-Concussion Symptoms Questionnaire....