Study reveals how brain tumors grow in a nutrient-starved environment

Researchers from The University of Texas MD Anderson Cancer Center (TX, USA) have discovered new details of how the enzyme, acetyl-CoA synthetase 2 (ACSS2), supports brain tumor growth in a nutrient-starved environment. The results from this study, recently published in Molecular Cell, may provide a new target for future cancer therapies. ACSS2 is an enzyme that allows tumors to increase their uptake of acetate when glucose is in a limited supply. Current therapies are inefficient at stopping this nutrient pathway due to the limited knowledge of how ACSS2 translocates from the cytosol to the nucleus of cells. Zhimin Lu (The...