Neurology Central

Alzheimer’s disease risk linked to gene network expressed in myeloid cells

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Scientists from the Icahn School of Medicine at Mount Sinai (IL, USA) have identified a network of genes expressed by myeloid cells that are linked to late-onset Alzheimer’s disease (AD). The study, published in Nature Neuroscience, identified PU.1, a transcription factor vital for the development and function of myeloid cells, as a master regulator of this network of AD risk genes. Further research is necessary to fully understand this network of genes and role of PU.1 in myeloid cells and AD.
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