Alzheimer’s disease risk linked to gene network expressed in myeloid cells

Scientists from the Icahn School of Medicine at Mount Sinai (IL, USA) have identified a network of genes expressed by myeloid cells that are linked to late-onset Alzheimer’s disease (AD). The study, published in Nature Neuroscience, identified PU.1, a transcription factor vital for the development and function of myeloid cells, as a master regulator of this network of AD risk genes. Further research is necessary to fully understand this network of genes and role of PU.1 in myeloid cells and AD. Alison Goate, Icahn School of Medicine at Mount Sinai, explained: “Our findings show that a large proportion of the...