Neurology Central

Future biomaterials for enhanced cell–substrate communication in spinal cord injury intervention

Neuro(bio)platforms, the extracellular matrix mimicking support structures formed and fabricated from biomaterials, constitute an inherent component of the regenerative strategies employed in neuro-trauma and -degeneration interventions. The choice of these bioplatforms is dependent on several physico-chemical and -mechanical characteristics of the constituent biomaterial(s) which in turn defines the intent (biocompatibility) and extent (biodegradability) of their stay in the neuroenvironment. These factors and features are further essential to realize the complex neuromimetic network formation capable of inherent axonal regeneration with no external mediation. This paradigm develops into an even more complex setting when such archetypes are loaded and seeded with biofactors and stem cells, respectively, and are commonly referred to as ‘combinatorial therapies’ [1]. Within these combinatorial platforms, there is an essential need of effective communication between the host substrate and the resident cells, with the latter building their own home at the expense of the former over an extended neuroresidence time.
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