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Effects of gabapentin, pregabalin and gastroretentive gabapentin on simulated driving, daytime sedation and cognition

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Analgesics prescribed to treat postherpetic neuralgia are known to cause sedation, but what are the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on sedation and cognitive function? Rao and Schmidt conducted a Phase I crossover study to investigate the relative impacts of these gabapentinoids on driving performance. The researchers also sought to characterize the effects of these three medications on cognition and subjective sedation and to examine correlations between these findings and plasma drug concentrations. Read the abstract below to find out more on this study, or read the full-text article in Pain Management here.

Aim: Randomized Phase I study examining the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on simulated driving performance, sedation and cognitive function in healthy volunteers (n = 32). Methods: Driving attentiveness, sleepiness and cognition were evaluated prior to subjects receiving study doses. Blood samples were collected during each treatment. Results: Subjects receiving gastroretentive gabapentin showed less change in variation in lateral lane position (p = 0.0275), less tremor (p = 0.0304) and fewer vision disturbances compared with gabapentin (p = 0.0177). Statistically significant decrease in One Card Learning Test performance was observed after treatment with gastroretentive gabapentin. Conclusion: Gastroretentive gabapentin demonstrated reduced driving impairment and lower scores on key neurotoxicity measures. Further studies in patients with postherpetic neuralgia are needed.

Click here to read the full article from Pain Management.

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