Neurology Central

Could aspirin help reduce Alzheimer’s-related amyloid plaques?

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According to scientists at Rush University Medical Center (IL, USA), a low-dose regimen of aspirin may reduce Alzheimer’s-related amyloid plaques in the brain – indicating a potential new role for this medication. The researchers believe that this could reduce Alzheimer’s disease (AD) pathology and protect memory.

Aspirin is one of the most widely used over-the-counter medications in the world, and works by activating PPARα to upregulate TFEB and increase lysosomal biogenesis in brain cells. TFEB is known as a master regulator of lysosomal biogenesis.

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