Neurology Central

AAIC 2018: Day 3 Update

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Video highlight

Catch up on our daily update from Day 1 here.

Catch up on our daily update from Day 2 here

Catch up on our daily update from Day 4 here

Today’s news

Pick of the posters

  • Imm J, Allen N, Jeffries A, Kerrigan T,  Lennon K. Epigenetic profiling of 33Qn1 iPSC cells throughout neuronal differentiation. This was an extremely interesting poster that went into using the Infinium HumanMethylationEPIC BeadChip Array to look at DNA methylation profile throughout neuronal differentiation, in order to ensure that inducing pluripotency and re-differentiation does not significantly affect iPSC-derived neural cells. An interesting finding from this poster revealed that iPSC cells display more hemi-methylation than the more differentiated cell types. Future research into this will involve extending the study to include long-term differentiated samples, iPSCs and neurons that are homozygous for apolipoprotein ε4.

 

  • Castanho I, Murray TK, Farbos A et al. Mapping genomic consequences of Alzheimer’s disease pathology in amyloid and tau mouse models. Isabel Castanho’s presentation of her work was really enlightening, as her study aimed to test the hypothesis that accumulation of tau pathology in the brain is associated with progressive changes in genomic regulation affecting biological systems related to the developing neuropathology. An interesting finding from this research included a significant upregulation of genes across development, which were extremely enriched for those involved in immune regulation. These neuropathology changes observed in the mouse models will be compared with data generated from ongoing studies of human Alzheimer’s disease.

 

  • Heale R, Stan D-M, Smyth L, Lace-Costigan G. Alterations in autophagy in frontotemporal dementia. Richard Heale did an excellent job at presenting his poster findings. His study aimed to investigate variation in macroautophagy (MA) and chaperone-mediated autophagy (CMA) marker distribution in frontotemporal dementia, by comparing frontotemporal dementia cases to aged-matched, no-disease controls and Alzheimer’s disease cases. An interesting finding from this poster revealed that there was a decrease in MA markers, which suggested a potential impairment in MA initiation and autophagosomal maturation in frontotemporal dementia cases with GRN mutations.

Picture of the day

We spotted #ENDALZ on a Chicago high rise! 

Today at our booth

Unfortunately, we ran out of British treats to giveaway at our booth today for the spin wheel, however, we were able to substitute these with some American sweets and chocolates to compensate! Our USBs, pens and tote bags are still available to win at our booth so do stop by for a chance to win them and to sign up for free.

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