Neurology Central

AAIC 2018: Could the gut–liver–brain axis control Alzheimer’s risk?

The interaction between the brain and the digestive system is a fairly new area of investigation with regards to Alzheimer’s disease (AD) and other dementias, however, four new studies presented at the Alzheimer’s Association International Conference (22–26 July, IL, USA) have reported evidence of associations between the digestive system and brain disorders.

In the past few years, researchers have uncovered various mechanisms by which brain health depends on the digestive system, such as associations between certain species in the gut microbiome and protein build-up in the brain.

An experiment on murine models recently suggested that a change of diet may influence the progression of Alzheimer’s, and another recent study demonstrated that APOE-e4, the main risk-factor gene for Alzheimer’s, is involved in lipid transport and metabolism.

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