Authors: Sharon Salt, Editor
An international team of researchers have successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice.
In the study, published in mBio®, the team demonstrate that a live, attenuated version of the Zika virus could form the basis of a new treatment option for this fatal brain cancer.
Glioblastoma is currently incurable because patients are reported to experience a high recurrence rate of their cancer even after standard treatments of surgery, radiation and chemotherapy. Researchers believe that this recurrence rate is due to glioblastoma stem cells (GSCs), which hide out in nearby brain tissue even after the combination of therapies.