Neurology Central

Could Alzheimer’s disease be kick-started by periodontal bacteria?

According to a new study from researchers at the University of Illinois at Chicago (IL, USA), long-term exposure to periodontal disease bacteria could cause inflammation and degeneration of neurons in mice that is similar to the effects of Alzheimer’s disease (AD) in humans.

In the study, which has been published in PLOS ONE, the researchers tested a hypothesis that repeated exposure of wild-type mice to orally administered Porphyromonas gingivalis results in neuroinflammation, neurodegeneration, microgliosis, astrogliosis and formation of intra- and extra-cellular amyloid plaque and neurofibrillary tangles.

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