Neurology Central

Blood–brain barrier on a chip offers opportunity for personalized treatment of neurological conditions

Researchers from Cedars-Sinai Medical Center (CA, USA) have created a blood–brain barrier (BBB) chip utilizing human induced pluripotent stem cells (iPSCs). Their paper, published in Cell Stem Cell, presents a novel method for analyzing drug interactions with the BBB and could also be utilized to further our understanding of neurological disorders.

Conditions such as Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis have been linked to defects in the BBB. To learn more about the role of the BBB in these diseases the research group combined Organ–Chip technology with human iPSC-derived tissue to create a BBB chip.

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