Neurology Central

Risk of dementia may be increased with certain anticholinergics, study suggests

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Certain types of commonly prescribed drugs used to treat bladder conditions, Parkinson’s disease and depression could significantly increase the risk of dementia later in life, according to a recent study.

The research, which has been published in JAMA Internal Medicine, was carried out by researchers from the University of Nottingham (UK). The team identified that there was a nearly 50% increased risk of dementia among patients aged 55 and over who had used strong anticholinergic medication daily for 3 years or more.

Within the nested case-control study, the investigators examined the medical records of 58,769 patients with a diagnosis of dementia and 225,574 patients without a diagnosis of dementia. All participants were aged 55 and over and registered with UK general practitioners contributing data to the QResearch database (between 1 January 2004 and 31 January 2016).

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