Neurology Central

Parkinson’s: new mouse model supports gut–brain connection

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Researchers from Johns Hopkins Medicine (MD, USA) have provided additional evidence to support the idea that Parkinson’s disease originates among cells in the gut and travels up the vagus nerve to the brain. This pathway was observed in a new mouse model, which recapitulates both motor and non-motor deficits as well as early-stage and late-stage features associated with Parkinson’s disease.

The results of their study have been published in the journal Neuron.

“Since this model starts in the gut, one can use it [to]study the full spectrum and time course of the pathogenesis of Parkinson’s disease,” commented said Ted Dawson (Johns Hopkins University), co-senior author of the study. “For instance, one could test preventive therapies at early pre-symptomatic stages of Parkinson’s disease all the way to full-blown Parkinson’s disease in one animal model.”

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