Neurology Central

AAIC 2019: How can sleep disruption be improved in individuals with dementia?

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Two treatment trials presented at the Alzheimer’s Association International Conference (14–18 July 2019, Los Angeles, CA, USA) demonstrate that both pharmacological and non-pharmacological methods can be used to improve sleep patterns in individuals with dementia.

Up to 45% of people living with Alzheimer’s disease and other dementias may experience problems when sleeping. “…Disrupted sleep patterns not only put the overall health of people with dementia at further risk, they may also worsen their memory loss and disrupted thinking,” explained Maria Carrillo, Chief Science Officer at the Alzheimer’s Association (IL, USA).

In a Phase II trial, a research group from Eisai Inc. (NJ, USA) investigated the effectiveness of the drug lemborexant on irregular sleep-wake rhythm disorder in people with Alzheimer’s. The participants of the study received different doses of the drug or a placebo and wore a sleep-monitoring device for the duration of the study.

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