Neurology Central

Can choline reduce Alzheimer’s-related symptoms in female mice?

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Currently, there are no effective therapies for the progression of Alzheimer’s disease (AD). Therefore, a team of researchers at ASU-Banner Neurodegenerative Disease Research Center (NDRC; AZ, USA) investigated whether the nutrient choline could alleviate the symptoms of AD.

Earlier in the year, the team discovered transgenerational benefits of AD-like symptoms in mice whose mothers were supplemented with choline. In this current study, published in Aging Cell, the researchers explored the effects of choline administered in mice during adulthood.

The team bred mice to develop AD-like symptoms and put them on either a control choline diet or high choline diet from 2.5–10 months of age. The researchers focused on female mice, as there is a higher prevalence of AD observed in human females.

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