Neurology Central

SfN19: How might the gut–brain connection impact brain health in mice?


Recent studies have suggested that intestinal bacteria imbalance has a role in disorders such as Alzheimer’s disease (AD) and traumatic brain injury. Having an increased understanding of the gut–brain connection via the immune system may help in developing new treatments for neurodegenerative diseases.

At SfN Neuroscience 2019 (19–23 October, Chicago, IL, USA), the abstracts of four studies investigating the impact of gut–brain communication on brain health in mice were presented.

“These are important contributions to our understanding of the complex relationship between the gut and the brain,” commented press conference moderator, Jane A Foster (McMaster University, Ontario, Canada).

Gut microbiome changes induced by antibiotic treatment may reduce amyloid-β (Aβ) plaques in mice and alter microglia

Researchers from the University of Chicago Medicine (IL, USA) have discovered a potential relationship between changes in the microbiome and AD pathology.

Using two transgenic mouse models of Aβ amyloidosis, the team of researchers established a strong association between the gut microbiome and cerebral Aβ plaque pathology as well as plaque-localized gliosis.

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