Neurology Central

Circadian disruption in the prodromal stages of dementia with Marco Brancaccio

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Circadian disruption is one of many physiological processes that have been implicated in Alzheimer’s disease. Over the last few years, this relationship has gained traction and researchers have been exploring how sleep and circadian disruption could be potential contributors to the risk and pathogenesis of the disease. However, the underlying mechanisms behind this bidirectional relationship remains unclear and our understanding of the potential processes behind this are still in their infancy.

To find out more about this, we spoke with Marco Brancaccio (UK DRI at Imperial College London, UK) at the UK–Korea Neuroscience Symposium (12–13 August, London, UK) to discuss what the mechanisms behind circadian disruption in the early stages of dementia might be. Marco also provided us with his opinions on what more needs to be done to successfully translate this research into the clinic.

Interview questions with Marco Brancaccio on circadian disruption and the early stages of dementia:

00:05 – Please can you introduce yourself and tell us more about your role?

00:21 – Could you give us an overview of your research?

01:24 – In your opinion, what do you think might be driving the mechanisms behind circadian dysfunction in the early stages of dementia?

02:09 – Can you tell us more about what techniques your lab is using to investigate this association?

02:40 – Lastly, what more needs to be done to successfully translate this into the clinic?

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