Authors: Heather Jones, Future Science Group
Researchers at Northwestern University (IL, USA) have demonstrated, using a mouse model, that ultrasound therapy could be an effective method for crossing the blood–brain barrier and treating glioblastoma. The study, published in Clinical Cancer Research, also revealed a new formulation of a standard drug that is both safer and more effective.
Though treatment options are available, glioblastoma currently has no cure. One obstacle to a successful long-term outcome in patients is the blood–brain barrier, which blocks current therapies from directly treating brain tumors. The current therapy, known as paclitaxel, is both unable to cross the blood–brain barrier and is toxic to the brain.
“Glioblastoma currently has no cure, and when the tumor recurs there are not many treatment options,” commented Adam Sonabend from Northwestern University, principle investigator for this study. “We urgently need effective new treatments.”