Neurology Central

Immune cells identified as therapeutic target for age-related cognitive decline in mice


A team of scientists from Albany Medical College (NY, USA) has identified that group 2 innate lymphoid cells (ILC2s) accumulate in aging brains. They determined that activation of these cells may prevent cognitive decline.

The paper, published in the Journal of Experimental Medicine, suggests that these cells could be a new target for the treatment of age-related neurodegenerative diseases.

Previous research has determined that ILC2s can reside in the meninges where they can play a role in tissue repair following spinal cord injury. “However, whether ILC2s also reside in other parts of the central nervous system, and how they respond to aging, was unknown,” explained Qi Yang (Albany Medical College).

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