Blood biomarkers for neurological disease research: current status, challenge and future outlook

Written by Liu Shi (Department of Psychiatry, University of Oxford, UK)

Biomarker discovery for neurological diseases is burgeoning due to the advances in technologies that permit molecular measures taken from the brain, cerebrospinal fluid (CSF), plasma, saliva, urine and so on. Biomarkers could be biochemical changes (proteins, metabolomics and lipids), genetic alteration or changes in structural or functional features. They could help the diagnosis and detect the progression of these diseases, referred to as diagnostic and prognostic markers, respectively. Furthermore, biomarkers could help to measure the efficacy of the treatments, known as predictive markers. The importance of biomarkers in neurological diseases should not be underestimated, particularly considering the large social and...

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