Cognitive/neurodegenerative disorders: All Phases trials

Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia (Lithium)

Lithium carbonate

Phase II

Frontotemporal dementia (FTD)

United States

Ongoing, not yet recruiting

https://clinicaltrials.gov/ct2/show/NCT02862210?term=neurodegenerative&rcv_s=07%2F25%2F2016&rcv_e=08%2F25%2F2016&lup_s=07%2F25%2F2016&lup_e=08%2F25%2F2016&rank=4


Conversations as a Means to Delay Alzheimer's Disease (AD) Onset (CESII)

Conversational Engagement

Phase II

Alzheimers disease

United States

Ongoing, not yet recruiting

https://clinicaltrials.gov/ct2/show/NCT02871921?term=neurodegenerative&rcv_s=07%2F25%2F2016&rcv_e=08%2F25%2F2016&lup_s=07%2F25%2F2016&lup_e=08%2F25%2F2016&rank=18


Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

Nelotanserin

Phase II

Dementia; Parkinsons; hallucinations; sleep behaviour disorder

United States

Recruiting (invitation only)

https://clinicaltrials.gov/ct2/show/NCT02871427?term=sleep&rcv_s=07%2F25%2F2016&rcv_e=08%2F25%2F2016&lup_s=07%2F25%2F2016&lup_e=08%2F25%2F2016&rank=3


A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2027 in Healthy Subjects

E2027

Phase I

Parkinsons, dementia

United States

Recruiting

https://clinicaltrials.gov/ct2/show/NCT02873156?term=parkinsons&rcv_s=07%2F25%2F2016&rcv_e=08%2F25%2F2016&lup_s=07%2F25%2F2016&lup_e=08%2F25%2F2016&rank=11


Efficacy and Safety of Tianzhi Granule in Mild to Moderate Vascular Dementia

Tianzhi granule

Phase III

Vascular dementia

China

Recruiting

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Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial

Tadalafil

Phase II

Vascular dementia

UK

Recruiting

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Efficacy of Pain Treatment on Depression in Patients With Dementia (DEP-PAIN-DEM)

Paracetamol; Buprenorphine

Phase III

Depression; pain; dementia

Norway

Recruiting

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DAOIB for the Treatment of Cognitive Function and Behavioral and Psychological Symptoms of Dementia

DAOIB

Phase II

Behavioral and Psychological Symptoms in Alzheimer's Disease & Vascular Dementia

Taiwan

Recruiting

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n-3 PUFA for Vascular Cognitive Aging

Omega 3 PUFA

Phase II

Age Related Cognitive Decline; Alzheimer's Disease; Vascular Dementia

USA

Recruiting

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Symptomatic Treatment of Vascular Cognitive Impairment (STREAM-VCI)

Galantamine; Methylphenidate

Phase II

Mild Cognitive Impairment (Vascular); Mild Cognitive Disorder (Vascular); Vascular Dementia

Recruiting

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Effect of Insulin Sensitizer Metformin on AD Biomarkers

Metformin

Phase II

Alzheimer's Disease; Vascular Dementia; Dementia

USA

Recruiting

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Safety Study of Dabigatran in CADASIL

Dabigatran; Antiplatelets

Phase II

CADASIL

Italy

Recruiting

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ADvance DBS-f in Patients With Mild Probable Alzheimer's Disease

DBSf (Deep Brain Stimulation of the Fornix)

Phase I

Alzheimer's (mild to moderate)

USA & Canada

Ongoing, not recruiting

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12 Month Open-label Study of RVT-101 in Subjects With Mild to Moderate Alzheimer's Disease: MINDSET Extension

RVT-101

Phase III

Alzheimer's (mild to moderate)

USA

Not yet recruiting

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Study Evaluating RVT-101 in Subjects With Mild to Moderate Alzheimer's Disease on Donepezil Treatment: MINDSET Study

RVT-101

Phase III

Alzheimer's (mild to moderate)

USA

Recruiting

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Efficacy and Safety of Tianzhi Granule in Mild to Moderate Vascular Dementia

Tianzhi granule

Phase III

China

Recruiting

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An Extension of the HORIZON Protocol Evaluating the Safety of Dimebon (Latrepirdine) in Subjects With Huntington Disease (HORIZON PLUS)

Dimebon (latrepirdine)

Phase III

Completed

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A Phase 2, to Evaluating the Safety and Efficacy of Pridopidine Versus Placebo for Symptomatic Treatment in Patients With Huntington's Disease

Pridopidine

Phase II

Multiple worldwide locations

Recruiting

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Phase IIb Study of Intranasal Glutathione in Parkinson's Disease ((in)GSH)

Reduced Glutathione

Phase II

United States

Recruiting

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Efficacy of Isradipine in Early Parkinson Disease

Isradipine

Phase III

United States, Canada

Recruiting

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Randomised Crossover Trial of Deep Brain Stimulation of Differential Posterior Subthalamic Area Regions in Parkinson's Disease and Tremor

Up to 3 mA, 60 us, 130 Hz deep brain stimulation, Empirical unblinded deep brain stimulation programming

Phase II

Australia

Recruiting

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Neuroinflammation and Cognitive Decline in Alzheimer Disease (NICAD)

ADAS-Cog evaluation

Phase I

France

Study is not yet open for participant recruitment

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Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients With Mild Alzheimer's Disease (STEADFAST)

Azeliragon

Phase III

United States, Canada

Recruiting

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Study of the Safety & Efficacy of Leukine® in the Treatment of Alzheimer's Disease

Sagramostim

Phase II

United States

Recruiting

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Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease

TRx0237 150 mg/day

Phase III

Multiple worldwide locations

Ongoing

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Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA (DOPS-AMS)

L-Threo DOPS

Phase II

France

Recruiting

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Treatment of Parkinson Disease and Multiple System Atrophy Using Intranasal Insulin

Intranasal Insulin

Phase II

United States

Recruiting

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Post-Stroke Disease Management - Stroke Card

Extended Standard Care (Stroke Card)

Phase III

Austria

Recruiting

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n-3 PUFA for Vascular Cognitive Aging

Omega 3 PUFA

Phase II

United States

Recruiting

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