Pain drug pipelines

AstraZeneca

MEDI7352

Pain

Phase I


Dainippon Sumitomo Pharma

DSP-2230

Pain

Phase I


Pfizer

PF-06412562

Pain

Phase I


Teva

TEV-90109

opioid addiction

Approval


Teva

Vantrela

pain

Approval


Teva

TV-46763

pain

Phase III


Teva

TV-45070 Topical

Neuropathic pain

Phase II


Teva

TEV-90105

pain

Phase I


Teva

TV-46139

pain

Phase I


Takeda

TAK-648

diabetic neuropathy

Discontinued Phase I


Takeda

fulranumab

pain

Human monoclonal antibody against human Nerve Growth Factor

Phase I


Sanofi

patisiran

Familial amyloidotic polyneuropathy

siRNA inhibitor targeting TTR

Phase III


Roche

RG6029

pain

small-molecule sodium channel blocker selective for Nav1.7

Phase I


Pfizer

tanezumab

Pain (lower back, cancer)

Nerve Growth Factor Inhibitor

Phase III


Pfizer

ALO-02 Oxycodone-naltrexone core

Pain

Mu-type opioid receptor (MOR-1) agonist

Preclinical


Novartis

EMA401

Neuropathic pain

Angiotensin ll receptor antagonist

Phase II


Johnson & Johnson

fulranumab

Pain (osteoarthritis)

Discontinued


Johnson & Johnson

Canagliflozin

diabetic neuropathy

Phase III


Celgene

PDA-002

Diabetic peripheral neuropathy

Phase II


Biogen

BIIB074 

trigeminal neuralgia

Nav 1.7 inhibitor

Phase II


Astellas

ASP3662

Diabetic peripheral neuropathy & Alzheimer's disease

11beta-HSD1 inhibitor

Phase I & II


Astellas

ASP8232

diabetic neuropathy

VAP-1 inhibitor

Phase II


Roche

RG7893

Pain

small-molecule sodium channel blocker selective for Nav1.7

Phase I


Eli lilly

Tanezumab

Pain (cancer, lower back & osteoarthritic)

monoclonal antibody - inhibition of nerve growth factor

Phase III


Sunovion

DSP-2230

Neuropathic pain

Phase I


Pfizer

Lyrica

Peripheral Neuropathic Pain

Alpha-2 Delta Ligand

Phase III


Pfizer

PF-05089771

Chronic Neuropathic Pain

Nav 1.7 Modulator

Phase II


Astellas

ASP8477

Neuropathic pain

HER1/EGFR tyrosine kinase inhibitor

Phase II


Teva Pharmaceutical Industries Ltd

TEV-48125

Chronic and episodic migraine

Anti-calcitonin gene-related peptide (CGRP) monoclonal antibody

Phase II


Teva Pharmaceutical Industries Ltd

TV-45070 Topical

Neuropathic pain

Phase II