HAE-4 antibody could remove amyloid plaques without promoting brain inflammation

Written by Alice Bough (Future Science Group)

A group based at Washington University School of Medicine in St. Louis (MO, USA) has identified an anti-amyloid antibody, HAE-4, that does not appear to increase the risk of brain bleeds. The results of the paper, published in Science Translational Medicine, looked at mouse models and suggest that HAE-4 could be a safer approach to treating Alzheimer’s disease than previously tested antibodies. Of the anti-amyloid antibodies that have been so far tested in clinical trials, all lead to the occurrence of amyloid-related imaging abnormalities, indicating swelling or bleeding in the brain. “Alzheimer’s researchers have been searching for decades for therapies...

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