New animal model suggests Alzheimer’s progression facilitated by amyloid-β plaques

Written by Roisin Conneely

Research published in Nature Medicine has presented an animal model for Alzheimer’s that incorporates both amyloid-β and tau pathologies and may allow for testing novel therapies in a more realistic context. Results from this study have suggested that amyloid-β facilitates connection between plaques and tau; hence such an interaction enhances the spread of mutated tau proteins and thus progression of the disease. The work is significant as previously researchers have attempted to study amyloid-β plaques but have faced difficulty in isolating the protein, as well as in determining its relationship with tau. This particular study may demonstrate Alzheimer’s development a...

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