Poor sleep quality associated with presence of Alzheimer’s disease biomarkers

A new research paper published in Neurology has investigated the relationship between sleep quality and the presence of Alzheimer’s disease (AD) biomarkers in the CSF. In this study, a total of 101 cognitively normal adults completed sleep assessments and CSF collection. CSF was analyzed for biomarkers of amyloid metabolism and plaques (Aβ42); tau pathology (p-tau 181); neuronal/axonal degeneration (t-tau, NFL); neuroinflammation/astroglial activation (MCP-1, YKL-40); and synaptic dysfunction/degeneration (neurogranin). It was observed that worse subjective sleep quality, more sleep problems and daytime sleepiness were associated with marker levels known to indicate AD pathology, including lower CSF Aβ42/Aβ40 and higher t-tau/Aβ42, p-tau/Aβ42,...