‘Resetting’ immune cells may improve recovery in mice following TBI, even months after injury

A recent study in the Journal of Neuroscience has indicated that targeting overactive immune cells and dampening their neurotoxic effects may offer new therapeutic strategies for traumatic brain injury (TBI). Once a TBI occurs, microglia morph into an inflammatory state to help protect the brain. However, long-term inflammation may contribute towards neurological degeneration after a TBI. Within this pre-clinical study, the researchers examined the effects of delayed depletion of chronically activated microglia on functional recovery and neurodegeneration up to 3 months post-injury in mice. The team reported that at 1-month post-injury, they were able to inhibit a receptor that is...