Alzheimer’s disease pathology reversed in mouse model
Researchers have observed improvements in the cognitive function of mice after reversing the formation of beta-amyloid plaques.
Browsing: mouse model
Novel gene target reveals antidepressant mechanism of electroconvulsive therapy
A new study implicates a novel gene target in the efficacy of electroconvulsive therapy as a depression treatment.
New small-molecule drug may restore brain function in mouse model of Alzheimer’s disease
Researchers have discovered that an experimental drug appears to block the flow of toxic ions thought to cause Alzheimer’s.
New animal model suggests Alzheimer’s progression facilitated by amyloid-β plaques
For the first time, researchers have been able to examine the exact link between amyloid- β and tau in an animal model of the Alzheimer’s brain, providing hope for new therapeutic targets.
Novel genes associated with hearing loss revealed by new study
An international consortium has used mouse knockouts to identify 52 novel genes associated with hearing.
Epileptic brain activity found in transgenic mouse lines
Neural activity resembling epileptic events has been found in multiple GCaMP6-expressing transgenic mouse lines, potentially complicating interpretation of neural activity in the lines.
Spinal muscular atrophy may be caused by synaptic abnormalities
Research suggests increasing synaptic activity could alleviate SMA symptoms: motor function of mice was improved when treated with a glutamate receptor stimulant.
Alzheimer’s-associated memory loss in mice prevented with targeted protein removal
Reducing mouse model brain levels of the protein Ephexin5 prevented the loss of excitatory synapses that typically leads to memory loss in Alzheimer’s disease.
Journal Watch: Lost in propagation – tau induces neuron loss and grid cell dysfunction in transgenic mice
Researchers at Colombia University, New York (NY, USA), have recently demonstrated that tau pathology induces dysfunction in cells specifically tuned to compute spatial information.
Angelman syndrome and Dup15q syndrome: two rare diseases working together to solve each other’s puzzles – a conversation with Jill Silverman and Nathalie Buscher
In this interview, Drs Silverman and Buscher discuss their work, and how these two rare diseases are shedding light not only on each other, but also a wealth of other neurological disorders.
