In this literature review, the authors discuss the pathophysiology of both acute and chronic neuropsychiatric sequelae of concussions, plus the evaluation and management of these.
Researchers have uncovered a role for the gene FKBP5 in memory formation following traumatic events, and suggest that manipulation of the gene could help prevent PTSD.
Mice with increased levels of kynurenic acid display behaviors similar to traits seen in schizophrenia patients.
This special report argues that many patients with chronic pain may not be significantly impacted by psychological factors, and that for those who are, cognitive–behavioral therapy is the treatment of choice.
Evaluation of over 10 million insurance claims in the USA provides evidence of “adverse selection” in the prescription of opioids.
Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support
In the study, the authors assess the impact of child abuse victimization on methylation of a novel CpG site located in a CpG island shore within the NR3C1 promoter and further assess the potential buffering effect of having received emotional support in childhood.
In this editorial, the authors focus on TBIs that result in brain hemorrhage. On the battlefield, it is likely to be overlooked in favor of more readily visible injuries, yet bleeding and inflammation within the head can cause death or pervasive ongoing psychiatric conditions.
Subchronic administration of phencyclidine produces hypermethylation in the parvalbumin gene promoter in rat brain
In this preliminary communication, the authors use the novel object recognition (NOR) paradigm to assess the efficacy of the treatment regime to induce cognitive deficits prior to the postmortem analysis.
Researchers at Washington University School of Medicine (St. Louis, MO, USA) have identified areas in the brains of children with Tourette’s syndrome that appear different when compared with the same areas in children without the disorder.
Chinese researchers have utilized MRI to demonstrate that children with PTSD experience disruptions in the structure of their neural networks.