Researchers have suggested that anti-amyloid therapies would be most effective before individuals reach the threshold for preclinical Alzheimer’s disease.
Studies in aged chimpanzees have identified neuropathological hallmarks similar to those observed in the human Alzheimer’s diseased brain.
Researchers have discovered a new mitochondrial mechanism behind Parkinson’s disease, which could have key implications for future treatment.
New research has demonstrated that a naturally occurring compound, squalamine, may prevent the formation of the α-synuclein aggregates that are characteristic of Parkinson’s disease onset.
A new study has demonstrated a distinctive pattern of unusual gene activity in the brains of autistic individuals; a finding that indicates several possible new drug targets.
This article puts forward the argument that neuropathology is not obsolete within dementia research, despite advances in neuroimaging and molecular biology techniques.
Researchers demonstrate that amyloid precursor proteins may lead to endosome enlargement, contributing to early Alzheimer’s disease pathologies.
Neurology Central talks to Ramesh Raghupathi (Drexel University; PA, USA) about his work in traumatic brain injury (TBI), investigating cell death and plasticity in a range of animal models of TBI.
The current status of assessment and treatment in pediatric catatonia is reviewed, as well as theories underlying the mechanism of the disorder.
This perspective discusses the role electron microscopy has played in the progression of Alzheimer’s research, focusing on the significance of organelles in the disease pathogenesis.