Preclinical data has demonstrated that an oral small molecule drug could inhibit the formation of neurotoxic tau oligomers in an animal model most relevant to Alzheimer’s disease.
A recently published study has indicated that eliminating microglia could significantly reduce tau-linked brain damage in mice, providing a path for novel treatments.
Researchers have utilized flortaucipir PET to identify tau protein tangles in the brains of individuals who have suffered just a single head injury.
Researchers have found that the sleep history and pattern of older men and women may predict the accumulation of proteins associated with Alzheimer’s disease.
In a study focused on a group of former professional athletes who have experienced multiple concussions, over half the group were reported to have higher levels of tau protein biomarkers in their cerebrospinal fluid.
An experimental PET scan was used to detect elevated levels of abnormal tau protein in regions of the brain affected by CTE in living former NFL players.
The Medical Research Council (MRC; London, UK) has determined the atomic structures of abnormal tau filaments related to chronic traumatic encephalopathy (CTE) and discovered that the structure is different to tau filaments seen in Alzheimer’s disease.
A recent study has revealed that people who experience sleep apnea also present with higher levels of tau in the entorhinal cortex.
In this research article from Biomarkers in Medicine, researchers determine if serum levels of tau and BDNF can be used as severity biomarkers in multiple sclerosis.
A recent study has implicated that sticky proteins associated with neurodegenerative diseases could be transferred in mouse models.