Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoancepahlopathy presenting with postpartum psychosis and late-onset stroke

Written by Paraskevas GP, Constantinides VC, Bougea A et al.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoancepahlopathy (CADASIL) due to ∼200 identified mutations in NOTCH 3 gene (chromosome 19) is the most common cause of inherited cerebral small vessel disease, inherited stroke and inherited vascular cognitive decline [1]. Typically, symptom onset is with migraine with aura at about the age of 30 years or early stroke at 41–50 years. Neuroimaging features include multiple and/or confluent ischemic lesions in the white matter and basal ganglia with characteristic involvement of the anterior temporal white matter and external capsule, usually in the absence of classical cardiovascular risk factors, such as hypertension, diabetes...

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