Latest News
Researchers have discovered subcellular signs of young-onset Parkinson’s disease that emerge before symptoms arise. Additionally, further testing has revealed a drug that may reverse these cellular abnormalities.
A recently published study has indicated that lithium, in doses of up to 400-times lower than what is currently being prescribed for mood disorders, could halt signs of advanced Alzheimer’s disease in rats.
PTC Therapeutics (NJ, USA) has announced positive topline results from part II of the FIREFISH trial, demonstrating that risdiplam was well tolerated in infants with Type 1 spinal muscular atrophy.
Journal Articles
In this research article from the Journal of Comparative Effectiveness Research, the authors assess the real-world outcomes among patients with Duchenne muscular dystrophy receiving deflazacort or prednisone in real-world practice.
This review article from the journal Pain Management provides a summary of national and international evidence-based guidelines for common pain conditions to guide primary healthcare practitioners on recommended non-prescription analgesic treatments.
In this interview from the Video Journal of Biomedicine, Hannah Brown (Ipsos Healthcare, London, UK) discusses physician and patient treatment decision-making for relapsing–remitting multiple sclerosis.
Autoimmune
Gut microbiome modulation: potential mechanism uncovered for the treatment of multiple sclerosis
Could hyaluronic acid contribute to chronic white matter injury?
Can living in a sunnier climate in your youth reduce the risk of MS?
Cerebrovascular disease
Gut to brain: short-chain fatty acids may hold potential to improve stroke recovery in mice
Traumatic microbleeds may predict worse outcomes following head injury
Blood pressure changes in mid-30s linked to poorer brain health
CNS/PNS/SNS
Personalized electrode placement may improve outcomes of deep brain stimulation
Ethical and social implications of neural–digital interfaces: an interview with Suzanne Rivera
Neuroprosthetic exoskeleton allows tetraplegic patient to utilize his limbs
Cognitive/neurodegenerative disorders
First signs of young-onset Parkinson’s detected in pluripotent stem cells
Could microdoses of lithium halt progression of Alzheimer’s disease in rats?
Probiotic bacteria prevent α-synuclein accumulation in a Parkinson’s disease model
Demyelinating disease
New flashing-light test may be able to determine multiple sclerosis drug success
Gut microbiome modulation: potential mechanism uncovered for the treatment of multiple sclerosis
Cannabis-based medicines for epilepsy and multiple sclerosis approved by NHS
Development and pediatrics
Risdiplam: positive topline results reported in FIREFISH trial for spinal muscular atrophy
Could sleep duration be associated with levels of circulating miRNAs in the blood?
SfN19: Brain organoids advance studies of neural development, research suggests
Epilepsy and seizure
EEG source analysis in epileptology: an interview with Stefan Rampp
Could a novel mechanism for synaptic plasticity hold potential for new epilepsy treatment?
Cannabis-based medicines for epilepsy and multiple sclerosis approved by NHS
Genetics
Pacifying pain: mouse study reveals a gene-therapy approach could be used to relieve chronic pain
Translating genetic data in Alzheimer’s into potential therapies with Owen Peters
Rare gene variant APOE3ch may hold clues to preventing Alzheimer’s disease
Headache
Emgality® achieves primary and secondary outcomes in Phase III trial for migraines
Acute migraine: novel therapy shows promise in Phase III trial
Why are migraines more common in women? New sex-specific insights revealed
Immune disorders and inflammation
Blood–brain barrier dysfunction may be an early trigger of neurological aging in mice
SfN19: Uncovering the complex interplay between microglia, neuroinflammation and disease pathology
Inflammatory disease and anxiety: could endocannabinoids be a mechanism of comorbidity?
Infection
Could a bacterial polysaccharide suppress fatal brain inflammation?
Link between Alzheimer’s disease and periodontal bacteria gains traction
Injury/trauma
The ENIGMA brain injury project and global data collaboration with Emily Dennis
Immune-modifying nanoparticles could reduce swelling after traumatic brain injury in mice
Movement disorders
First signs of young-onset Parkinson’s detected in pluripotent stem cells
Probiotic bacteria prevent α-synuclein accumulation in a Parkinson’s disease model
Nilotinib could be a safe and effective treatment for Parkinson’s disease
Neuro-ophthalmology
New flashing-light test may be able to determine multiple sclerosis drug success
Neurometabolic
Epigenetics, opioids and immune regulation: interviews from SfN17
Jeffrey Iliff: glymphatics, Alzheimer’s and future directions
SfN17: Neurodegeneration and the microbiome – new research highlights
Neuromuscular
First signs of young-onset Parkinson’s detected in pluripotent stem cells
Neuropsychiatry
Can gut bacteria improve mental health after spinal cord injury?
The link between auditory stimuli and fear behavior, new neural pathway identified in mice
World Mental Health Day: facts, figures and the flaws of academia
Oncology/tumor
Artificial intelligence algorithm accurately identifies brain tumors, study reveals
Ultrasound therapy successful in directly treating glioblastoma tumors in mice
Pain
Developing neurotechnologies for spinal cord injuries with Grégoire Courtine
Pacifying pain: mouse study reveals a gene-therapy approach could be used to relieve chronic pain
Non-prescription drugs recommended in guidelines for common pain conditions
Sleep
Could sleep duration be associated with levels of circulating miRNAs in the blood?
Circadian disruption in the prodromal stages of dementia with Marco Brancaccio
Could circadian rhythms influence immune response efficiency in mice?
