Latest News
High-grade gliomas may be able to wire themselves into the healthy brain, receiving and interpreting electrical signals from normal neurons.
This week in industry includes trials on elenbecestat to be discontinued, ofatumumab demonstrating superiority to Aubagio and the Toca 5 trial results failing to meet primary endpoint.
In a large data study, researchers discover that terazosin, a drug typically used to treat enlarged prostate, might be able to slow down neurodegeneration in Parkinson’s disease.
Journal Articles
In this interview from the Video Journal of Biomedicine, Hannah Brown (Ipsos Healthcare, London, UK) discusses physician and patient treatment decision-making for relapsing–remitting multiple sclerosis.
Take a look behind the scenes of a study published in Brain, as we ask Dr Ryan D’Arcy about the establishment of brain vital signs for concussion-related impairments.
Discover more about an ongoing, multicenter registry that provides real-world evidence regarding ataluren use in nonsense mutation Duchenne muscular dystrophy patients in this research article.
Autoimmune
Could hyaluronic acid contribute to chronic white matter injury?
Can living in a sunnier climate in your youth reduce the risk of MS?
Cerebrovascular disease
Blood pressure changes in mid-30s linked to poorer brain health
Age-related cognitive changes may be reduced with intensive blood pressure control
Hypertension drug increases cerebral blood flow in people with Alzheimer’s, study suggests
CNS/PNS/SNS
Electrical patterns in ‘mini-brains’ can’t be distinguished from premature babies, study reveals
Nerve transfer surgery restores hand and arm function
EAN 2019: Neural clock and internal ‘GPS’ may provide valuable insights into Alzheimer’s disease
Cognitive/neurodegenerative disorders
Ask the Experts: The future of dementia research
Genetic therapies for neurodegenerative diseases: an interview with Sarah Tabrizi
Blood pressure changes in mid-30s linked to poorer brain health
Demyelinating disease
Ofatumumab demonstrates superiority over Aubagio® for relapsing MS: industry news round-up
‘Smoldering’ spots: a hallmark for progressive multiple sclerosis?
Development and pediatrics
Researchers challenge the ‘extreme male brain’ theory of autism
Electrical patterns in ‘mini-brains’ can’t be distinguished from premature babies, study reveals
Epilepsy and seizure
Genetics
Genetic therapies for neurodegenerative diseases: an interview with Sarah Tabrizi
Brain architecture linked to genetic regions in left-handed people
Headache
Emgality® achieves primary and secondary outcomes in Phase III trial for migraines
Acute migraine: novel therapy shows promise in Phase III trial
Why are migraines more common in women? New sex-specific insights revealed
Immune disorders and inflammation
Inflammatory disease and anxiety: could endocannabinoids be a mechanism of comorbidity?
FENS 2018: Immune system offers new way of treating Alzheimer’s disease
FENS 2018: Could anxiety and inflammation be treated with cannabis?
Infection
Could a bacterial polysaccharide suppress fatal brain inflammation?
Link between Alzheimer’s disease and periodontal bacteria gains traction
Injury/trauma
Metformin may help promote brain repair in female mice
Single traumatic brain injury can result in accumulation of tau protein, study reveals
Movement disorders
Parkinson’s progression could be slowed down by drug that treats enlarged prostate
Ofatumumab demonstrates superiority over Aubagio® for relapsing MS: industry news round-up
Study reveals the potential role of α-synuclein in DNA repair as a new target for Parkinson’s
Neuro-ophthalmology
Gene therapy breakthrough allows mice to regain sight
Could an eye scan detect signs of Alzheimer's disease?
Vision in Alzheimer's disease: a focus on the anterior afferent pathway
Neurometabolic
Epigenetics, opioids and immune regulation: interviews from SfN17
Jeffrey Iliff: glymphatics, Alzheimer’s and future directions
SfN17: Neurodegeneration and the microbiome – new research highlights
Neuromuscular
New genetic suspects identified for ALS and FTD
Novel discovery in motor neuron disease may pave the way for future treatments
Neuropsychiatry
Could psychiatric disorders be triggered by air pollution?
Addiction: a compulsive interplay between drugs, cues and habits
Galanin identified as new therapeutic target for the treatment of depression
Oncology/tumor
High-grade gliomas may hijack signals from neurons to drive their own growth
Glioblastoma: could a blood test be on the horizon?
Veledimex: a drug-inducible gene therapy approach for glioblastoma yields promising Phase I results
Pain
Emgality® achieves primary and secondary outcomes in Phase III trial for migraines
Advances in migraine genetics, neurobiology and treatment
Acute migraine: novel therapy shows promise in Phase III trial
Sleep
Could how much you sleep depend on your genes?
Acute light exposure at night doesn’t affect circadian rhythm in mice, research suggests
AAIC 2019: Sleep medications may increase dementia risk depending on race and gender
