Latest News
This week in industry we’re taking a look at the discontinuation of umibecestat and Acthar® Gel for Alzheimer’s and ALS, respectively, as well as the drug discovery shift from the amyloid approach in the Alzheimer’s field.
New studies presented at AAIC 2019 reveal that sex-specific differences could play a role in the risk, progression and resilience of Alzheimer’s disease.
Studies presented at AAIC 2019 have revealed the significant advances being made in the global search for blood-based biomarkers for dementia.
Journal Articles
In this review article, published in the journal Immunotherapy, the authors explore immunotherapy for neuroblastoma from therapeutic backbone to the latest discoveries.
Take a look behind the scenes of a recent paper in Biomarkers in Medicine as we ask the author about oligomeric α-synuclein in basal tears of Parkinson’s patients.
In this Editorial published in Immunotherapy, researchers explore the use of antibodies directed against amyloid-β oligomers for Alzheimer’s disease.
Autoimmune
Could hyaluronic acid contribute to chronic white matter injury?
Can living in a sunnier climate in your youth reduce the risk of MS?
Cerebrovascular disease
Hypertension drug increases cerebral blood flow in people with Alzheimer’s, study suggests
Regenerative stroke therapies: an interview with Steven Cramer
Stroke recovery: could the microbiome be a new therapeutic option?
CNS/PNS/SNS
Nerve transfer surgery restores hand and arm function
EAN 2019: Neural clock and internal ‘GPS’ may provide valuable insights into Alzheimer’s disease
New technology generates synthetic speech using brain activity
Cognitive/neurodegenerative disorders
Phase II/III trials of umibecestat to discontinue for Alzheimer’s disease: industry news round-up
AAIC 2019: Why is Alzheimer’s disease more prevalent in women? Sex-specific differences reported
AAIC 2019: Are we one step closer to finding a blood test for Alzheimer’s?
Demyelinating disease
EAN 2019: Does multiple sclerosis increase risk of developing cancer?
Multiple sclerosis: determining the dynamic nature of oligodendrocyte regeneration
Biomarker discovery and development in multiple sclerosis: where are we now?
Development and pediatrics
Spinraza®: positive long-term data reported in pre-symptomatic infants
Is exercise the newest way to re-tune brain structure in mice with autism spectrum disorder?
Autism linked to mutations in ‘junk’ DNA and not specific genes, study reveals
Epilepsy and seizure
WHO releases first global report on epilepsy
tRNAs: a blood-based biomarker for predicting seizures?
Children’s brains remap and retain visual perception after surgery for severe epilepsy
Genetics
Early-onset Alzheimer’s disease linked to high LDL cholesterol levels
Autism linked to mutations in ‘junk’ DNA and not specific genes, study reveals
Ask the Experts: Gene therapies in neurological diseases (Part II: challenges and future outlooks)
Headache
Acute migraine: novel therapy shows promise in Phase III trial
Why are migraines more common in women? New sex-specific insights revealed
US FDA warns of stroke risk with multiple sclerosis drug: industry news round-up
Immune disorders and inflammation
Inflammatory disease and anxiety: could endocannabinoids be a mechanism of comorbidity?
FENS 2018: Immune system offers new way of treating Alzheimer’s disease
FENS 2018: Could anxiety and inflammation be treated with cannabis?
Infection
Could a bacterial polysaccharide suppress fatal brain inflammation?
Link between Alzheimer’s disease and periodontal bacteria gains traction
Injury/trauma
Nerve transfer surgery restores hand and arm function
Can inflammatory biomarkers predict recovery time after concussion?
Movement disorders
Parkinson’s: new mouse model supports gut–brain connection
Study reveals possible early signs of Parkinson’s in the brain
Neuro-ophthalmology
Gene therapy breakthrough allows mice to regain sight
Could an eye scan detect signs of Alzheimer's disease?
Vision in Alzheimer's disease: a focus on the anterior afferent pathway
Neurometabolic
Epigenetics, opioids and immune regulation: interviews from SfN17
Jeffrey Iliff: glymphatics, Alzheimer’s and future directions
SfN17: Neurodegeneration and the microbiome – new research highlights
Neuromuscular
New genetic suspects identified for ALS and FTD
Novel discovery in motor neuron disease may pave the way for future treatments
EAN 2017: Guillain-Barré syndrome risk associated with month of birth
Neuropsychiatry
Addiction: a compulsive interplay between drugs, cues and habits
Galanin identified as new therapeutic target for the treatment of depression
Brain ‘fingerprinting’: a whole-system perspective into psychiatric conditions
Oncology/tumor
Risk of Alzheimer’s may be raised by hormone therapy for prostate cancer
EAN 2019: Does multiple sclerosis increase risk of developing cancer?
Depatux-M fails to meet primary endpoint in late-stage trial for newly diagnosed glioblastoma
Pain
Acute migraine: novel therapy shows promise in Phase III trial
Why are migraines more common in women? New sex-specific insights revealed
Could neuropathic pain be treated by modulation of immune cells?
Sleep
AAIC 2019: Sleep medications may increase dementia risk depending on race and gender
AAIC 2019: How can sleep disruption be improved in individuals with dementia?
Late-life Alzheimer’s pathology may be predicted with sleep history
