Latest News
At the Clinical Trials on Alzheimer’s Disease Congress this week, Biogen (MA, USA) has provided a detailed report on the latest aducanumab results, including why there was such a difference in the results between ENGAGE and EMERGE.
A recent set of studies reports how blood–brain barrier leakage may affect inflammation in the brain, potentially leading to acceleration of neurological aging in mice.
Artificial neurons have been developed in a first-of-its-kind achievement that closely resemble biological neurons, mimicking their responses to a range of stimulations.
Journal Articles
In this interview from the Video Journal of Biomedicine, Hannah Brown (Ipsos Healthcare, London, UK) discusses physician and patient treatment decision-making for relapsing–remitting multiple sclerosis.
Take a look behind the scenes of a study published in Brain, as we ask Dr Ryan D’Arcy about the establishment of brain vital signs for concussion-related impairments.
Discover more about an ongoing, multicenter registry that provides real-world evidence regarding ataluren use in nonsense mutation Duchenne muscular dystrophy patients in this research article.
Autoimmune
Gut microbiome modulation: potential mechanism uncovered for the treatment of multiple sclerosis
Could hyaluronic acid contribute to chronic white matter injury?
Can living in a sunnier climate in your youth reduce the risk of MS?
Cerebrovascular disease
Traumatic microbleeds may predict worse outcomes following head injury
Blood pressure changes in mid-30s linked to poorer brain health
Age-related cognitive changes may be reduced with intensive blood pressure control
CNS/PNS/SNS
Ethical and social implications of neural–digital interfaces: an interview with Suzanne Rivera
Neuroprosthetic exoskeleton allows tetraplegic patient to utilize his limbs
Traumatic CNS injury and the inflammatory stem cell niche: an interview with Aileen Anderson
Cognitive/neurodegenerative disorders
Aducanumab update: detailed data reported on 'resurrected' Alzheimer’s drug
Blood–brain barrier dysfunction may be an early trigger of neurological aging in mice
Artificial neurons developed that may help combat chronic diseases, such as Alzheimer’s
Demyelinating disease
Gut microbiome modulation: potential mechanism uncovered for the treatment of multiple sclerosis
Cannabis-based medicines for epilepsy and multiple sclerosis approved by NHS
Unraveling the heterogeneity of oligodendrocytes with Ana Mendanha Falcão
Development and pediatrics
SfN19: Brain organoids advance studies of neural development, research suggests
SfN19: Advances in autism research could pave way for early intervention and treatment
Epilepsy and seizure
Could a novel mechanism for synaptic plasticity hold potential for new epilepsy treatment?
Cannabis-based medicines for epilepsy and multiple sclerosis approved by NHS
Dynorphin-based gene therapy demonstrates long-term suppression of seizures
Genetics
Translating genetic data in Alzheimer’s into potential therapies with Owen Peters
Rare gene variant APOE3ch may hold clues to preventing Alzheimer’s disease
Genetic therapies for neurodegenerative diseases: an interview with Sarah Tabrizi
Headache
Emgality® achieves primary and secondary outcomes in Phase III trial for migraines
Acute migraine: novel therapy shows promise in Phase III trial
Why are migraines more common in women? New sex-specific insights revealed
Immune disorders and inflammation
Blood–brain barrier dysfunction may be an early trigger of neurological aging in mice
SfN19: Uncovering the complex interplay between microglia, neuroinflammation and disease pathology
Inflammatory disease and anxiety: could endocannabinoids be a mechanism of comorbidity?
Infection
Could a bacterial polysaccharide suppress fatal brain inflammation?
Link between Alzheimer’s disease and periodontal bacteria gains traction
Injury/trauma
Concussion could alter transmission of information within the brain
SfN19: How might the gut–brain connection impact brain health in mice?
Tranexamic acid could reduce head injury deaths by ‘hundreds of thousands’
Movement disorders
Gut microbiome modulation: potential mechanism uncovered for the treatment of multiple sclerosis
Neuroprosthetic exoskeleton allows tetraplegic patient to utilize his limbs
Parkinson’s progression could be slowed down by drug that treats enlarged prostate
Neuro-ophthalmology
Gene therapy breakthrough allows mice to regain sight
Could an eye scan detect signs of Alzheimer's disease?
Vision in Alzheimer's disease: a focus on the anterior afferent pathway
Neurometabolic
Epigenetics, opioids and immune regulation: interviews from SfN17
Jeffrey Iliff: glymphatics, Alzheimer’s and future directions
SfN17: Neurodegeneration and the microbiome – new research highlights
Neuromuscular
New genetic suspects identified for ALS and FTD
Novel discovery in motor neuron disease may pave the way for future treatments
Neuropsychiatry
The link between auditory stimuli and fear behavior, new neural pathway identified in mice
World Mental Health Day: facts, figures and the flaws of academia
Oncology/tumor
Can artificial intelligence speed up brain tumor diagnosis?
Liquid biopsy could predict prognosis of glioblastoma, study suggests
High-grade gliomas may hijack signals from neurons to drive their own growth
Pain
Emgality® achieves primary and secondary outcomes in Phase III trial for migraines
Advances in migraine genetics, neurobiology and treatment
Acute migraine: novel therapy shows promise in Phase III trial
Sleep
Circadian disruption in the prodromal stages of dementia with Marco Brancaccio
Could circadian rhythms influence immune response efficiency in mice?
