Latest News
Research conducted in mice has revealed that ‘resetting’ immune cells could improve recovery following traumatic brain injury, even months after the injury has occurred.
Using stem cell-derived BrainSpheres, also known as ‘mini-brains’, researchers have detected harmful side effects of a common antidepressant drug on the developing brain. This novel model for drug testing could provide a good alternative to traditional animal testing.
Machine-learning techniques have identified variability among the brain networks of children, which could help inform personalized treatments for psychiatric disorders.
Journal Articles
Take a peek behind the scenes of a recently published study in the journal Nanomedicine as we ask first author, Filippo Rossi (Politecnico di Milano, Italy), about the challenges in moving nanovector-based therapies into the clinic for spinal cord injuries.
Take a look behind the scenes of a recent Review paper from Neurodegenerative Disease Management as we ask first author, Jiwon Oh (University of Toronto, Canada), about the diagnostic and management issues surrounding progressive multiple sclerosis.
In this research article from the Journal of Comparative Effectiveness Research, the authors assess the real-world outcomes among patients with Duchenne muscular dystrophy receiving deflazacort or prednisone in real-world practice.
Autoimmune
Gut microbiome modulation: potential mechanism uncovered for the treatment of multiple sclerosis
Could hyaluronic acid contribute to chronic white matter injury?
Can living in a sunnier climate in your youth reduce the risk of MS?
Cerebrovascular disease
Transcranial magnetic stimulation and stroke rehabilitation: an interview with Kathy Ruddy
Gut to brain: short-chain fatty acids may hold potential to improve stroke recovery in mice
Traumatic microbleeds may predict worse outcomes following head injury
CNS/PNS/SNS
Consciousness can be regained following stimulation of central lateral thalamus, study reveals
Personalized electrode placement may improve outcomes of deep brain stimulation
Cognitive/neurodegenerative disorders
Rare Disease Day – a closer look into Batten disease
Could tau protein accumulation be prevented by removing β-arrestin-2 oligomers?
DIAN-TU: solanezumab and gantenerumab yield disappointing results for rare form of Alzheimer’s
Demyelinating disease
New flashing-light test may be able to determine multiple sclerosis drug success
Gut microbiome modulation: potential mechanism uncovered for the treatment of multiple sclerosis
Development and pediatrics
BrainSpheres: antidepressant yields harmful effects on lab-grown ‘mini-brains’
Risdiplam: positive topline results reported in FIREFISH trial for spinal muscular atrophy
Could sleep duration be associated with levels of circulating miRNAs in the blood?
Epilepsy and seizure
EEG source analysis in epileptology: an interview with Stefan Rampp
Could a novel mechanism for synaptic plasticity hold potential for new epilepsy treatment?
Cannabis-based medicines for epilepsy and multiple sclerosis approved by NHS
Genetics
Rare Disease Day – a closer look into Batten disease
Pacifying pain: mouse study reveals a gene-therapy approach could be used to relieve chronic pain
Translating genetic data in Alzheimer’s into potential therapies with Owen Peters
Headache
Emgality® achieves primary and secondary outcomes in Phase III trial for migraines
Acute migraine: novel therapy shows promise in Phase III trial
Why are migraines more common in women? New sex-specific insights revealed
Immune disorders and inflammation
Immune cells identified as therapeutic target for age-related cognitive decline in mice
Blood–brain barrier dysfunction may be an early trigger of neurological aging in mice
SfN19: Uncovering the complex interplay between microglia, neuroinflammation and disease pathology
Infection
Could a bacterial polysaccharide suppress fatal brain inflammation?
Link between Alzheimer’s disease and periodontal bacteria gains traction
Injury/trauma
‘Resetting’ immune cells may improve recovery in mice following TBI, even months after injury
Molecular imaging of tau pathology after traumatic brain injury with Nikos Gorgoraptis
The ENIGMA brain injury project and global data collaboration with Emily Dennis
Movement disorders
Parkinson’s vs multiple system atrophy: could new technology distinguish between the two?
First signs of young-onset Parkinson’s detected in pluripotent stem cells
Probiotic bacteria prevent α-synuclein accumulation in a Parkinson’s disease model
Neuro-ophthalmology
Vision-related brain cells mimicked using nanoscale device
New flashing-light test may be able to determine multiple sclerosis drug success
Neurometabolic
Epigenetics, opioids and immune regulation: interviews from SfN17
Jeffrey Iliff: glymphatics, Alzheimer’s and future directions
SfN17: Neurodegeneration and the microbiome – new research highlights
Neuromuscular
First signs of young-onset Parkinson’s detected in pluripotent stem cells
Neuropsychiatry
BrainSpheres: antidepressant yields harmful effects on lab-grown ‘mini-brains’
Personalized brain networks have been identified in children
Is the brain to blame? Long-term antisocial behavior may be linked to differences in brain structure
Oncology/tumor
World Cancer Day 2020: the biggest neuro-oncology developments of the year
Artificial intelligence algorithm accurately identifies brain tumors, study reveals
Ultrasound therapy successful in directly treating glioblastoma tumors in mice
Pain
Developing neurotechnologies for spinal cord injuries with Grégoire Courtine
Pacifying pain: mouse study reveals a gene-therapy approach could be used to relieve chronic pain
Non-prescription drugs recommended in guidelines for common pain conditions
Sleep
Could sleep duration be associated with levels of circulating miRNAs in the blood?
Circadian disruption in the prodromal stages of dementia with Marco Brancaccio
Could circadian rhythms influence immune response efficiency in mice?
