Does DNA instability contribute to schizophrenia?

Written by Lauren Pulling

Researchers from Nagoya University (Japan) have conducted a highly sensitive genetic analysis to identify DNA sequence repeats that may play a role in schizophrenia. They demonstrated that patients with schizophrenia may have more DNA sequence repeats than control individuals, indicating a possible link between genome instability and the characteristics of the disease. Previous studies have indicated a link between copy number variations (CNVs) and disease, including schizophrenia. Specifically, rare CNVs on chromosomes 1, 15, 16 and 22 are more common in schizophrenia patients than control individuals. However, previous research has not fully established the relationship between specific CNVs, particularly those...

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