Dream duo could reverse stroke induced brain damage

Written by Adam Price-Evans

A team of researchers led by Berislav Zlokovic (University of California, CA, USA) has developed a novel therapeutic technique that holds promise for reversing stroke-induced long-term disability. The approach involves the utilization of a US FDA-approved protein to drive the formation of functional neurons. Activated protein C (APC) is a blood protease involved with regulating anticoagulation and various cell signaling pathways. Formerly studied as a neuroprotectant in ischemic stroke patients, a recombinant variant of APC, termed 3K3A-APC, has been demonstrated to stimulate the production of neurons from human stem cells grafted into the stroke-damaged mouse brain. The team transplanted human...

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